Invitrogen™ Talin Monoclonal Antibody (8D4)

Catalog No.	Quantity
PIMA547740	100 μL

Catalog No. PIMA547740

Supplier: Invitrogen™ MA547740

Description

Mouse Monoclonal Antibody

The antibody detects a 240 kDa* protein corresponding to the molecular mass of Talin on SDS-PAGE immunoblots of human A431, rat PC12, and rabbit fibroblast cells.

Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-235 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin.

Specifications

• Antigen: Talin
• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 8D4
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
• Gene: TLN2
• Gene Accession No.: P26039, P54939, Q71LX4, Q9Y490, Q9Y4G6
• Gene Alias: 5730421P04Rik; AI507121; AI787438; AL118320; ILWEQ; KIAA0320; KIAA1027; mKIAA0320; RGD1565416; talin 1; talin 2; talin-1; Talin-2; TLN; Tln1; Tln2
• Gene Symbols: TLN1, TLN2
• Host Species: Mouse
• Immunogen: Clone 8D4 was generated from purified chicken gizzard talin. The antibody recognizes an epitope within the rod domain of talin from many species, including human, rat, mouse, chicken, and frog.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 21894, 313494, 315776, 395194, 415374, 70549, 7094, 83660
• Target Species: Human, Mouse, Rat, Chicken
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1