Tamoxifen citrate

Description

Inhibitor of protein kinase C and induces apoptosis in cancer cells | CAS: 54965-24-1 | C32H37NO8 | 563.65 g/mol

Tamoxifen citrate is used as an antiestrogen with potent anti-cancer and PKC inhibitory activities. Tamoxifen Citrate functions as an estrogen receptor antagonist in breast tissue. Tamoxifen Citrate is an agonist towards this receptor in tissues of the endometrium. Tamoxifen Citrate inhibits DNA synthesis and transcription by recruiting co-repressors, which stop estrogen from interacting with genes. When combined with PAX2, Tamoxifen Citrate can inhibit the proliferation of ERBB2. It is also a high affinity activator of the GPR30 receptor. Tamoxifen Citrate is an activator of Estrogen Receptor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tamoxifen citrate is used as an antiestrogen with potent anti-cancer and PKC inhibitory activities. Tamoxifen Citrate functions as an estrogen receptor antagonist in breast tissue. Tamoxifen Citrate is an agonist towards this receptor in tissues of the endometrium. Tamoxifen Citrate inhibits DNA synthesis and transcription by recruiting co-repressors, which stop estrogen from interacting with genes. When combined with PAX2, Tamoxifen Citrate can inhibit the proliferation of ERBB2. It is also a high affinity activator of the GPR30 receptor. Tamoxifen Citrate is an activator of Estrogen Receptor.

Solubility
Soluble in methanol (50 mg/ml with heat) or ethanol (10 mg/ml with sonication); very slightly soluble in water (0.3 mg/L @ 20°C; the pH is approximately 3.0-3.5), 0.02 N HCl (0.2 mg/ml @ 37°C)4, acetone ,chloroform,and DMSO(100mM)

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 54965-24-1
• Molecular Formula: C32H37NO8
• Molecular Weight (g/mol): 563.65
• MDL Number: MFCD00058321
• InChI Key: FQZYTYWMLGAPFJ-OQKDUQJOSA-N
• Synonym: tamoxifen citrate, istubal, zitazonium, unii-7frv7310n6, i.c.i. 46474 citrate, tamoxifen citrate salt, farmifeno, ginarsan, jenoxifen
• PubChem CID: 2733525
• ChEBI: CHEBI:9397
• IUPAC Name: (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine; 2-hydroxypropane-1,2,3-tricarboxylic acid
• SMILES: OC(=O)CC(O)(CC(O)=O)C(O)=O.CC\C(=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1

• Color: White
• Quantity: 5 g
• Sensitivity: Hygroscopic; Light sensitive
• Merck Index: 14,9048
• Solubility Information: Soluble in methanol (50mg/ml with heat) or ethanol (10mg/ml with sonication); very slightly soluble in water (0.3mg/L @ 20°C; the pH is approximately 3.0-3.5),0.02 N HCl (0.2mg/ml @ 37°C)4,acetone ,chloroform,and DMSO(100mM)
• Formula Weight: 563.65
• Physical Form: Powder
• Chemical Name or Material: Tamoxifen citrate

Safety and Handling

Hazard Category	H302-H350
Hazard Statement	GHS H Statement H350-H360-H362-H302 May cause cancer. May damage fertility or the unborn child. May cause harm to breast-fed children. Harmful if swallowed.
Precautionary Statement	P201-P202-P264b-P270-P281-P301+P312-P308+P313-P330-P501c
EINECSNumber	259-415-2
RTECSNumber	KH2387000
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only