Tamoxifen, MP Biomedicals

Description

Tamoxifen, White Powder

• It has been used to facilitate the recombination of ect2flox allele in mouse organs.
• It has also been used to study its effect on lipopolysaccharide (LPS)-induced microglial activation.
• Protein kinase C inhibitor (IC50 = 50-200μM depending on assay conditions in MCF-7 cells or IC50 = 100μM in rat brain).
• It is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4.

Specifications

Chemical Identifiers

• CAS: 10540-29-1
• Molecular Formula: C26H29NO
• Molecular Weight (g/mol): 371.52
• MDL Number: MFCD00010454
• InChI Key: NKANXQFJJICGDU-QPLCGJKRSA-N
• SMILES: CC\C(=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1

• Melting Point: 96°C to 100°C
• Color: White
• Loss on Drying: 0.0021
• Refractive Index: KR5919600
• Quantity: 5 g
• Synonym: [Z]-1-[p-Dimethylaminoethoxyphenyl]-1,2-diphenyl-1-butene, (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine, ICI 47699, trans-Tamoxifen
• Solubility Information: Practically insoluble in water (< 0.01% at 20°C); soluble in methanol, ethanol, 2-propanol, propyleneglycol, chloroform (50mg/mL - clear, colorless to faint yellow solution) or DMSO
• IUPAC Name: (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine
• Physical Form: Powder
• Assay: 0.9935

Safety and Handling

storageNote1

Store at +4°C.

WARNING: Cancer - www.P65Warnings.ca.gov