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Tocris Bioscience™ TAT-cyclo-CLLFVY

Catalog No. 55821
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Quantity:
1 mg
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Catalog No. 55-821

Supplier: Tocris Bioscience™ 5582/1

This item is not returnable. View return policy

Description

Selective HIF-1 dimerization inhibitor

TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM) . Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.

Specifications

Purity 95%
CAS 1446322-66-2
Content And Storage Store at -20°C
Description HIF Inhibitors
Molecular Weight (g/mol) Observed M.W.: 2559.1
Quantity 1 mg
Structural Form C111H188N42O24S2
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