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  5. Tocris Bioscience™ Tazemetostat

Tocris Bioscience™ Tazemetostat

Catalog No. 809310
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80-931-0 10 mg
80-935-0 50 mg
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Catalog No. 80-931-0 Supplier Tocris Bioscience™ Supplier No. 8093/10
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Description

Potent and selective EZH2 inhibitor

Tazemetostat is a potent and selective EZH2 inhibitor (Ki = 2.5 nM; IC50 = 11 nM). Reduces H3K27me3 levels in PDX derived cells and inhibits cellular H3K27 methylation. Tazemetostat suppresses EZH2 and MYC expression and induces neuronal differentiation genes; also increases neurite extension in MB-39-nu cells. Antiproliferative in SMARCAB1-deleted MRT cell lines (IC50 = 32 - 1000 nM); inhibits methylation in both mutant and wild type cells (IC50 = 1.4-4.9 nM). Dose-dependently suppresses growth of both MC38 cells and tumors in vivo.

Specifications

Chemical Name or Material N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4'-(4-morpholinylmethyl)[1,1'-biphenyl]-3-carboxamide
CAS 1403254-99-8
Quantity 10 mg
Target EZH2 Inhibitor
Molecular Formula C34H44N4O4
Purity 0.97
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