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Invitrogen™ TBK1 Polyclonal Antibody
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Catalog No. PIPA517478
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100 μL
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PIPA517478 100 μL
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Catalog No. PIPA517478 Supplier Invitrogen™ Supplier No. PA517478
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Description

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody.

TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling. TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKK beta, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKK beta through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TBK1
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 131 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 0.15M NaCl, 50% glycerol, 100μg/mL BSA and no preservative; pH 7.5
Gene TBK1
Gene Accession No. Q9UHD2, Q9WUN2
Gene Alias 1200008B05Rik; AI462036; AW048562; FLJ11330; FTDALS4; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; tbk; TBK1
Gene Symbols TBK1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues near the carboxy-terminus of TBK1/NAK.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29110, 299827, 56480
Target Species Human, Mouse, Monkey, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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