Invitrogen™ TBL1X/TBL1XR1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA19108

Catalog No. 01-674-388

Description

This antibody is expected to recognize the human protein TBL1XR1 (NP_078941) as well as TBL1X. Variants (NP_005638.1; NP_001132938.1) encode isoform a (TBL1X) and variants (NP_001132939.1; NP_001132940.1 ) encode isoform b (TBL1X). This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.

Specifications

• Antigen: TBL1X/TBL1XR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TBL1X
• Gene Alias: 5330429M20; 8030499H02Rik; A630076E03Rik; AW539987; C21; C230089I12Rik; DC42; EBI; F-box-like/WD repeat protein TBL1XR1; F-box-like/WD repeat-containing protein TBL1X; F-box-like/WD repeat-containing protein TBL1XR1; Ira1; MRD41; nuclear receptor co-repressor/HDAC3 complex subunit; nuclear receptor corepressor/HDAC3 complex subunit TBLR1; SMAP55; TBL1; TBL1-related protein 1; Tbl1x; Tbl1xr1; TBLR1; transducin (beta)-like 1 X-linked; transducin (beta)-like 1 X-linked receptor 1; transducin (beta)-like 1X-linked; transducin (beta)-like 1X-linked receptor 1; transducin beta-like 1X-related protein 1; Transducin beta-like protein 1X; transducin-beta-like protein 1, X-linked
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 6907, 79718
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O60907, Q9BZK7
• Gene Symbols: TBL1X, Tbl1xr1
• Immunogen: Synthetic peptide corresponding to the C terminus amino acids SASDGSVCVLDLRK (aa 564-577).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG