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TBX21/T-bet Rabbit anti-Human, Mouse, Polyclonal, Proteintech
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Catalog No. 501728943 Shop All Proteintech Group Inc Products
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50-172-8943 150 μL
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Catalog No. 50-172-8943 Supplier Proteintech Group Inc Supplier No. 137001AP150UL
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Description

Rabbit Polyclonal Antibody

T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal transducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.

Specifications

Antigen TBX21/T-bet
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.13 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TBX21
Gene Accession No. Q9JKD8, Q9UL17
Gene Alias T bet, T box 21, T box protein 21, T PET, TBET, TBLYM, TBX21, TBX21,T bet, Transcription factor TBLYM
Gene Symbols Tbx21
Host Species Rabbit
Immunogen TBX21,T-bet Fusion Protein Ag4618
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 30009, 57765
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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