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Invitrogen™ TCF7L2 Polyclonal Antibody
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Catalog No. PIPA585993
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100 μL
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PIPA585993 100 μL
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Catalog No. PIPA585993 Supplier Invitrogen™ Supplier No. PA585993
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Description

Rabbit Polyclonal Antibody

TCF7L2 Polyclonal Antibody for Flow, ICC/IF, IHC (P), Western Blot

TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCF7L2
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% Glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
Gene Tcf7l2
Gene Accession No. Q924A0, Q9NQB0
Gene Alias HMG box transcription factor 4; hTCF; hTCF 4; hTCF-4; mTCF-4; mTcf-4B; mTcf-4E; RP11-357H24.1; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF 4; TCF4; TCF-4; TCF4B; TCF4E; Tcf7l2; TCF7L2 protein; transcription factor 7 like 2; transcription factor 7 like 2, T cell specific, HMG box; transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box; transcription factor Tcf4
Gene Symbols Tcf7l2
Host Species Rabbit
Immunogen Synthetic peptide within N-terminal Human TCF7L2 aa 1-50.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21416, 679869, 6934
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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