TCF7L2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-9033	Proteintech Group Inc 138381AP150UL	150 μL

Description

TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.

Specifications

• Antigen: TCF7L2
• Applications: Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q924A0, Q9NQB0
• Gene ID (Entrez): 21416, 679869, 6934
• Immunogen: TCF7L2 Fusion Protein Ag4786
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: TCF7L2

• Concentration: 0.23 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: HMG box transcription factor 4, hTCF 4, T cell factor 4, TCF 4, TCF4, TCF7L2, Transcription factor 7 like 2
• Gene Symbols: Tcf7l2
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody