TCF7L2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-172-9033	150 μL

Catalog No. 50-172-9033 Supplier Proteintech Group Inc Supplier No. 138381AP150UL

Description

Rabbit Polyclonal Antibody

TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.

Specifications

• Antigen: TCF7L2
• Applications: Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.23 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: TCF7L2
• Gene Accession No.: Q924A0, Q9NQB0
• Gene Alias: HMG box transcription factor 4, hTCF 4, T cell factor 4, TCF 4, TCF4, TCF7L2, Transcription factor 7 like 2
• Gene Symbols: Tcf7l2
• Host Species: Rabbit
• Immunogen: TCF7L2 Fusion Protein Ag4786
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 21416, 679869, 6934
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG