Invitrogen™ TCL1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587465

Catalog No. PIPA587465

Description

Immunogen sequence: MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD; Positive Samples: Ramos; Cellular Location: Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus.

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha or TCR-beta regulatory elements (summarized by Virgilio et al., 1998). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (Laine et al., 2000).

Specifications

• Antigen: TCL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TCL1A
• Gene Alias: oncogene TCL1; Oncogene TCL-1; Protein p14 TCL1; T cell lymphoma breakpoint 1; T-cell leukemia/lymphoma 1A; T-cell leukemia/lymphoma protein 1A; T-cell leukemia/lymphoma protein 1A (P14 TCL1 protein) (TCL1 oncogene) (TCL-1 protein); T-cell lymphoma breakpoint 1; T-cell lymphoma-1; T-cell lymphoma-1A; TCL1; TCL-1; TCL1A
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8115
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.63 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P56279
• Gene Symbols: TCL1A
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human TCL1A (NP_0010921951).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG