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  6. Invitrogen™ TCR beta Monoclonal Antibody (H57-597), Brilliant Violet™ 421, eBioscience™, Invitrogen™ 

Invitrogen™ TCR beta Monoclonal Antibody (H57-597), Brilliant Violet™ 421, eBioscience™, Invitrogen™
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Catalog No. 404596182
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40-459-6182 100 μg
40-459-6180 25 μg
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Catalog No. 40-459-6182 Supplier Invitrogen™ Supplier No. 404596182
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Description

Armenian Hamster Monoclonal Antibody

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
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Specifications

Antigen TCR beta
Applications Flow Cytometry
Classification Monoclonal
Clone H57-597
Concentration 0.2 mg/mL
Conjugate Brilliant Violet 421
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Tcrb
Gene Alias bTCR; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; T cell receptor beta chain; t-cell antigen receptor; T-cell receptor; TCR beta; Tcra; Tcrb; TCRbeta; TCRD; Tib; TRA
Gene Symbols Tcrb
Host Species Armenian Hamster
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21577
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Format liquid
Isotype IgG
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