Invitrogen™ TCR delta Monoclonal Antibody (TS-1)

Catalog No.	Quantity
PITCR1055	200 μg

Catalog No. PITCR1055 Supplier Invitrogen™ Supplier No. TCR1055

Description

Mouse Monoclonal Antibody

TCR1055 targets TCR Delta TCS1 in FACS, IHC(F), IP, and TCA applications and shows reactivity with Human samples. The TCR1055 immunogen is human TCR Vdelta1-Jdelta1. TCR1055 detects TCR Delta TCS1 which has a predicted molecular weight of approximately 17 kDa.

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Specifications

• Antigen: TCR delta
• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, T-Cell Activation
• Classification: Monoclonal
• Clone: TS-1
• Concentration: 0.15 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.5% BSA and 0.1% sodium azide
• Gene: TRDV1
• Gene Accession No.: A0A1B0GX56
• Gene Alias: CD3 antigen; CD3d antigen; OKT3
• Gene Symbols: TRD, TRDV1
• Host Species: Mouse
• Immunogen: Human TCR Vdelta1-Jdelta1.
• Purification Method: Purified
• Quantity: 200 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 28518, 6964
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1

Safety and Handling

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