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  6. Invitrogen™ TCR gamma/delta Monoclonal Antibody (5A6.E9), FITC 

Invitrogen™ TCR gamma/delta Monoclonal Antibody (5A6.E9), FITC
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Catalog No. MHGD01
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500 μL
2 mL
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MHGD01 500 μL
MHGD014 2 mL
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Description

Mouse Monoclonal Antibody

Commonly used, FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.

TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCR gamma/delta
Applications Flow Cytometry
Classification Monoclonal
Clone 5A6.E9
Conjugate FITC
Formulation PBS with 4mg/mL BSA and 0.1% sodium azide
Gene TRD
Gene Alias RGD1311300; similar to T cell receptor V delta 6; T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@
Gene Symbols TRD, Trg
Host Species Mouse
Immunogen Human TCR gamma/delta T cell receptor.
Purification Method Purified
Quantity 500 μL
Regulatory Status ASR
Primary or Secondary Primary
Gene ID (Entrez) 6964, 6965
Target Species Human
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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