Invitrogen™ TCR V alpha 12.1 Monoclonal Antibody (6D6.6)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ TCR1764

Catalog No. PITCR1764

Description

TCR V alpha 12.1 Monoclonal Antibody for Western Blot, IHC (F), Flow, IP, TCA

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Specifications

• Antigen: TCR V alpha 12.1
• Classification: Monoclonal
• Concentration: 0.15 mg/mL
• Formulation: PBS with 0.5% BSA and 0.1% sodium azide
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, T-Cell Activation, Western Blot
• Clone: 6D6.6
• Conjugate: Unconjugated
• Gene Alias: TCRVA; TCRVA 12.1; V alpha 12.1; V alpha-12.1 TCR
• Immunogen: Human TCR V alpha 12.1.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid