Invitrogen™ TCR V beta 5a Monoclonal Antibody (1C1), FITC

Catalog No.	Quantity
ENTCR2642	200 Tests

Catalog No. ENTCR2642 Supplier Invitrogen™ Supplier No. TCR2642

Description

Mouse Monoclonal Antibody

TCR2642 targets TCR V beta 5a in FACS, IHC(F), and TCA applications and shows reactivity with Human, Mouse and Non-human primate samples. The TCR2642 immunogen is human TCR V beta 5(a).

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Specifications

• Antigen: TCR V beta 5a
• Applications: Flow Cytometry, Immunohistochemistry (Frozen), T-Cell Activation
• Classification: Monoclonal
• Clone: 1C1
• Concentration: 0.5 mg/mL
• Conjugate: FITC
• Formulation: PBS with 0.5% BSA and 0.1% sodium azide
• Gene: TCRB
• Gene Accession No.: 0
• Gene Alias: T cell receptor beta chain; T cell receptor beta locus; TCRB; TCRbeta; Tib; TRB; TRB@
• Gene Symbols: TCRB
• Host Species: Mouse
• Immunogen: Human TCR V beta 5(a).
• Purification Method: Protein G
• Quantity: 200 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 21577
• Target Species: Human, Mouse, Monkey
• Content And Storage: 4°C, store in dark
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1