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Invitrogen™ TCR V gamma 9 Monoclonal Antibody (7A5), FITC
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Catalog No. TCR2720
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200 Tests
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TCR2720 200 Tests
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Catalog No. TCR2720 Supplier Invitrogen™ Supplier No. TCR2720
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Description

Mouse Monoclonal Antibody

TCR2720 targets TCR V gamma 9 in FACS applications and shows reactivity with Human, and Non-human primate samples. The TCR2720 immunogen is human TCR Vgamma9.

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
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Specifications

Antigen TCR V gamma 9
Applications Flow Cytometry
Classification Monoclonal
Clone 7A5
Concentration 0.1 mg/mL
Conjugate FITC
Formulation PBS with 0.5% BSA and 0.1% sodium azide
Gene TRG
Gene Accession No. 0
Gene Symbols TRG
Host Species Mouse
Immunogen Human TCR Vgamma9.
Purification Method Protein A
Quantity 200 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6965
Target Species Human, Monkey
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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