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TCS 2312, Tocris Bioscience™

Catalog No. 30381
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30-381 1 mg
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Catalog No. 30-381 Supplier R&D Systems Supplier No. 3038/1
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Description

Potent Chk1 inhibitor

Potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.

Chemical Identifiers

CAS 838823-31-7
Molecular Formula C25H24N4O2
Molecular Weight (g/mol) 412.493
InChI Key BYFCMDWKTJJQGR-UHFFFAOYSA-N
Synonym 4'-5-3-cyclopropylamino methyl phenyl amino-1h-pyrazol-3-yl-1,1'-biphenyl-2,4-diol, 4-5-4-cyclopropylaminomethyl-phenylamino-2h-pyrazol-3-yl-biphenyl-2,4-diol, tc0
PubChem CID 11258443
IUPAC Name 4-[4-[5-[4-[(cyclopropylamino)methyl]anilino]-1,2-dihydropyrazol-3-ylidene]cyclohexa-2,5-dien-1-ylidene]-3-hydroxycyclohexa-2,5-dien-1-one
SMILES C1CC1NCC2=CC=C(C=C2)NC3=CC(=C4C=CC(=C5C=CC(=O)C=C5O)C=C4)NN3

Specifications

Quantity 1 mg
Formula Weight 412.48
Percent Purity >97%
Chemical Name or Material TCS 2312

Safety and Handling

Recommended Storage Store at -20°C
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