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Invitrogen™ TDP-43 Monoclonal Antibody (3H8)
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Catalog No. PIMA547420 Shop All Thermo Scientific Products
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PIMA547420 100 μL
PIMA547322 500 μL
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Catalog No. PIMA547420 Supplier Invitrogen™ Supplier No. MA547420
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Description

Mouse Monoclonal Antibody

TDP-43 Monoclonal Antibody for Western Blot, ICC/IF, IHC (PFA)

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3'e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TDP-43
Applications Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 3H8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 5mM sodium azide
Gene TARDBP
Gene Accession No. Q13148, Q921F2
Gene Alias 1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg
Gene Symbols TARDBP
Host Species Mouse
Immunogen Full length recombinant human TDP43 expressed in and purified from E. coli.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100051482, 100739753, 230908, 23435, 298648, 540632
Target Species Human, Mouse, Rat, Bovine, Pig, Horse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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