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Invitrogen™ TEF1 Monoclonal Antibody (GT13112)
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Catalog No. PIMA527786
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100 μL
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PIMA527786 100 μL
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Catalog No. PIMA527786 Supplier Invitrogen™ Supplier No. MA527786
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Description

Mouse Monoclonal Antibody

Positive Control: HeLa NE Predicted Reactivity: Pig (100%), Chicken (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TEF1 (Transcriptional enhancer factor 1), a member of the TEA/ATTS domain family, is a nuclear protein that is expressed in numerous cell types and plays a role in controlling the expression of numerous genes. TEF family members have a highly conserved DNA-binding domain TEF-1 binds to GT-IIC, SphI/II and M-CAT. TEF-1 also binds to the proximal regulatory element (PRE) of transforming growth factor-alpha, a member of the EGF family that is overexpressed in many types of cancer. Furthermore, TEF-1 represses transcription in placental cells. In vitro, TEF-1 is phosphorylated by several PKC isozymes. TEF-1 is phosphorylated in vivo at serine and threonine residues. Phosphorylation of TEF-1, both in vivo and in vitro, results in a reduction in its DNA-binding capability, which suggests a potential role for TEF-1 in PKC inhibition. TEF-1 also complexes with larger tumor antigen (TAg), and may thus have a role in tumorigenesis. Dimerization of TEF-1 may be important for TEF-1 to function as a regulator of gene transcription.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TEF1
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone GT13112
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and no preservative; pH 7
Gene Tead1
Gene Accession No. P28347
Gene Alias 2610024B07Rik; AA; B230114H05Rik; Gtrgeo5; mTEF-1; N TEAD1; NTEF1; NTEF-1; protein GT-IIC; REF1; Tcf13; TCF-13; TEA domain family member 1; TEA domain family member 1 (SV40 transcriptional enhancer factor); TEA domain transcription factor 1; TEAD1; TEAD-1; TEF1; TEF-1; Transcription factor 13; transcriptional enhancer factor 1; transcriptional enhancer factor TEF-1
Gene Symbols Tead1
Host Species Mouse
Immunogen Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human TEF1. The exact sequence is proprietary.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7003
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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