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TEF1 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA5120213
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100 μL
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PIPA5120213 100 μL
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Catalog No. PIPA5120213 Supplier Thermo Scientific Supplier No. PA5120213
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Description

Rabbit Polyclonal Antibody

Positive test controls include: 293T, HeLa, Mouse skeletal muscle, Mouse heart, Rat heart. The target is usually found in the following locations: Nucleus. Immunogen sequence: APSVPAWQGR SIGTTKLRLV EFSAFLEQQR DPDSYNKHLF VHIGHANHSY SDPLLESVDI RQIYDKFPEK KGGLKELFGK GPQNAFFLVK FWADLNCNIQ D

TEF1 (Transcriptional enhancer factor 1), a member of the TEA/ATTS domain family, is a nuclear protein that is expressed in numerous cell types and plays a role in controlling the expression of numerous genes. TEF family members have a highly conserved DNA-binding domain TEF-1 binds to GT-IIC, SphI/II and M-CAT. TEF-1 also binds to the proximal regulatory element (PRE) of transforming growth factor-alpha, a member of the EGF family that is overexpressed in many types of cancer. Furthermore, TEF-1 represses transcription in placental cells. In vitro, TEF-1 is phosphorylated by several PKC isozymes. TEF-1 is phosphorylated in vivo at serine and threonine residues. Phosphorylation of TEF-1, both in vivo and in vitro, results in a reduction in its DNA-binding capability, which suggests a potential role for TEF-1 in PKC inhibition. TEF-1 also complexes with larger tumor antigen (TAg), and may thus have a role in tumorigenesis. Dimerization of TEF-1 may be important for TEF-1 to function as a regulator of gene transcription.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TEF1
Applications ChIP Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 2.16 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Tead1
Gene Accession No. P28347, P30051
Gene Alias 2610024B07Rik; AA; B230114H05Rik; Gtrgeo5; mTEF-1; N TEAD1; NTEF1; NTEF-1; protein GT-IIC; REF1; Tcf13; TCF-13; TEA domain family member 1; TEA domain family member 1 (SV40 transcriptional enhancer factor); TEA domain transcription factor 1; TEAD1; TEAD-1; TEF1; TEF-1; Transcription factor 13; transcriptional enhancer factor 1; transcriptional enhancer factor TEF-1
Gene Symbols Tead1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 200-300 of human TEAD1 (NP_068780.2).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21676, 361630, 7003
Target Species Human, Mouse, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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