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TEF1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA5120213

Description
Positive test controls include: 293T, HeLa, Mouse skeletal muscle, Mouse heart, Rat heart. The target is usually found in the following locations: Nucleus. Immunogen sequence: APSVPAWQGR SIGTTKLRLV EFSAFLEQQR DPDSYNKHLF VHIGHANHSY SDPLLESVDI RQIYDKFPEK KGGLKELFGK GPQNAFFLVK FWADLNCNIQ D
TEF1 (Transcriptional enhancer factor 1), a member of the TEA/ATTS domain family, is a nuclear protein that is expressed in numerous cell types and plays a role in controlling the expression of numerous genes. TEF family members have a highly conserved DNA-binding domain TEF-1 binds to GT-IIC, SphI/II and M-CAT. TEF-1 also binds to the proximal regulatory element (PRE) of transforming growth factor-alpha, a member of the EGF family that is overexpressed in many types of cancer. Furthermore, TEF-1 represses transcription in placental cells. In vitro, TEF-1 is phosphorylated by several PKC isozymes. TEF-1 is phosphorylated in vivo at serine and threonine residues. Phosphorylation of TEF-1, both in vivo and in vitro, results in a reduction in its DNA-binding capability, which suggests a potential role for TEF-1 in PKC inhibition. TEF-1 also complexes with larger tumor antigen (TAg), and may thus have a role in tumorigenesis. Dimerization of TEF-1 may be important for TEF-1 to function as a regulator of gene transcription.
Specifications
TEF1 | |
Polyclonal | |
Unconjugated | |
Tead1 | |
2610024B07Rik; AA; B230114H05Rik; Gtrgeo5; mTEF-1; N TEAD1; NTEF1; NTEF-1; protein GT-IIC; REF1; Tcf13; TCF-13; TEA domain family member 1; TEA domain family member 1 (SV40 transcriptional enhancer factor); TEA domain transcription factor 1; TEAD1; TEAD-1; TEF1; TEF-1; Transcription factor 13; transcriptional enhancer factor 1; transcriptional enhancer factor TEF-1 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
21676, 361630, 7003 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
ChIP Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
2.16 mg/mL | |
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3 | |
P28347, P30051 | |
Tead1 | |
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human TEAD1 (NP_068780.2). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
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