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TET1 Recombinant Mouse Monoclonal Antibody, AbFlex™, Active Motif™
SDP

Catalog No. 501993728
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50-199-3728 10 μg
50-199-3727 100 μg
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Catalog No. 50-199-3728 Supplier Active Motif Supplier No. 91172
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Description

Mouse Recombinant Monoclonal Antibody

Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.

Specifications

Antigen TET1
Applications ChIP sequencing (ChIP-seq), Western Blot
Classification Monoclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 140mM HEPES, 35mM sodium acetate with 30% glycerol, 70mM NaCl and 0.035% sodium azide; pH 7.5
Gene TET1
Gene Accession No. Q3URK3, Q8NFU7
Gene Alias 2510010B09Rik; AA517754; bA119F7.1; BB001228; CXXC finger 6; CXXC zinc finger 6; CXXC6; CXXC-type zinc finger protein 6; D10Ertd17e; KIAA1676; LCX; Leukemia-associated protein with a CXXC domain; Methylcytosine dioxygenase TET1; mKIAA1676; MLL-TET1; RP11-119F7.1; Ten-eleven translocation 1 gene protein; Ten-eleven translocation 1 gene protein homolog; ten-eleven translocation-1; tet methylcytosine dioxygenase 1; tet oncogene 1; Tet1; TET1 splice variant VP_DE4; TET1 splice variant VP_DE456; TET1-MLL
Gene Symbols TET1
Host Species Mouse
Immunogen This antibody was raised against a recombinant protein comprising amino acids 1682-1914 of mouse TET1 (Ten-Eleven Translocation-1; methylcytosine dioxygenase).
Purification Method Protein A
Quantity 10 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 52463, 80312
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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