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  6. Tet2 Monoclonal Antibody (21F11), Active Motif™ 

Tet2 Monoclonal Antibody (21F11), Active Motif™
SDP

Catalog No. p-7188879
Encompass
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50-199-3366 10 μg
50-199-3367 50 μg
50-199-3365 100 μg
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Catalog No. 50-199-3366 Supplier Active Motif Supplier No. 61390
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Description

Mouse Monoclonal Antibody

TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydromethylcytosine (5hmC) and plays a key role in active DNA demethylation. TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs. It mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and conversion of 5fC to 5-carboyxlcytosine (5caC). Conversion of 5mC into 5hmC, 5fC, and 5caC probably constitutes the first step in cytonsine demethylation. In addition to TET2’s role in DNA demethylation, it is also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Mutations in the genes can result in Polycythemia vera and Myelodysplastic syndrome.

Specifications

Antigen Tet2
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 21F11
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene TET2
Gene Accession No. Q6N021
Gene Alias Ayu17-449; E130014J05Rik; FLJ20032; KIAA1546; MDS; Methylcytosine dioxygenase TET2; MGC125715; mKIAA1546; Nbla00191; OTTHUMP00000161869; probable methylcytosine dioxygenase TET2; Protein Ayu17 449; Protein Ayu17-449; RGD1311625; Tet 2; tet methylcytosine dioxygenase 2; tet oncogene 2; tet oncogene family member 2; Tet2
Gene Symbols TET2
Host Species Mouse
Immunogen This antibody was raised against a recombinant protein corresponding to amino acids 1-300 of human Tet2.
Purification Method Protein A
Quantity 10 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54790
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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