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Tet2 Monoclonal Antibody (21F11), Active Motif™
Mouse Monoclonal Antibody
$145.44 - $572.16
Specifications
| Antigen | Tet2 |
|---|---|
| Clone | 21F11 |
| Concentration | 1 mg/mL |
| Applications | Immunoprecipitation, Western Blot |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-199-3366
|
Active Motif
61390 |
10 μg |
Each for $145.44
|
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|
50-199-3367
|
Active Motif
61990 |
50 μg |
Each for $333.30
|
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|
50-199-3365
|
Active Motif
61389 |
100 μg |
Each for $572.16
|
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Description
TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydromethylcytosine (5hmC) and plays a key role in active DNA demethylation. TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs. It mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and conversion of 5fC to 5-carboyxlcytosine (5caC). Conversion of 5mC into 5hmC, 5fC, and 5caC probably constitutes the first step in cytonsine demethylation. In addition to TET2’s role in DNA demethylation, it is also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Mutations in the genes can result in Polycythemia vera and Myelodysplastic syndrome.Specifications
| Tet2 | |
| 1 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with 30% glycerol and 0.035% sodium azide; pH 7.5 | |
| Ayu17-449; E130014J05Rik; FLJ20032; KIAA1546; MDS; Methylcytosine dioxygenase TET2; MGC125715; mKIAA1546; Nbla00191; OTTHUMP00000161869; probable methylcytosine dioxygenase TET2; Protein Ayu17 449; Protein Ayu17-449; RGD1311625; Tet 2; tet methylcytosine dioxygenase 2; tet oncogene 2; tet oncogene family member 2; Tet2 | |
| TET2 | |
| IgG1 κ | |
| Protein A | |
| Antibody |
| 21F11 | |
| Immunoprecipitation, Western Blot | |
| Unconjugated | |
| Mouse | |
| Human | |
| Q6N021 | |
| 54790 | |
| This antibody was raised against a recombinant protein corresponding to amino acids 1-300 of human Tet2. | |
| Primary | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| TET2 |
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