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TET2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Catalog No. 50560683 Shop All Proteintech Group Inc Products
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50-560-683 150 μL
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Catalog No. 50-560-683 Supplier Proteintech Group Inc Supplier No. 212071AP150UL
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Description

Rabbit Polyclonal Antibody

This antibody recognizes all three isoforms of TET2.

TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydromethylcytosine (5hmC) and plays a key role in active DNA demethylation. TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs. It mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and conversion of 5fC to 5-carboyxlcytosine (5caC). Conversion of 5mC into 5hmC, 5fC, and 5caC probably constitutes the first step in cytonsine demethylation. In addition to TET2′s role in DNA demethylation, it is also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Mutations in the genes can result in Polycythemia vera and Myelodysplastic syndrome.

Specifications

Antigen TET2
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TET2
Gene Accession No. Q4JK59, Q6N021
Gene Alias KIAA1546, tet oncogene family member 2, TET2
Gene Symbols TET2
Host Species Rabbit
Immunogen TET2 Fusion Protein Ag15583
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 214133, 54790
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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