Tetraethyl methylenediphosphonate, 98+%

Description

CAS: 1660-94-2 | C9H22O6P2 | 288.22 g/mol

Tetraethyl methylidenediphosphonate is used in the synthesis of tetrazoloquinoline-based mono- and bisphosphonate esters. It acts as an intermediate for the synthesis of bisphosphonate and bisphosphonic acid derivatives with anticancer and antischistosomal activity. It is also used as a reactant for synthesis of dual substrate-site inhibitors of 3-deoxy-D-arabino-heputosonate 7-phosphate synthase and alpha-amino acid derivatives containing gem-biophosphonates, Lycopene through Wittig-Horner reaction. It is also used as a precursor for the preparation of dendritic polyglycerol anions.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tetraethyl methylidenediphosphonate is used in the synthesis of tetrazoloquinoline-based mono- and bisphosphonate esters. It acts as an intermediate for the synthesis of bisphosphonate and bisphosphonic acid derivatives with anticancer and antischistosomal activity. It is also used as a reactant for synthesis of dual substrate-site inhibitors of 3-deoxy-D-arabino-heputosonate 7-phosphate synthase and alpha-amino acid derivatives containing gem-biophosphonates, Lycopene through Wittig-Horner reaction. It is also used as a precursor for the preparation of dendritic polyglycerol anions.

Solubility
Slightly miscible with water.

Notes
Incompatible with strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 1660-94-2
• Molecular Formula: C9H22O6P2
• Molecular Weight (g/mol): 288.22
• MDL Number: MFCD00039887
• InChI Key: STJWVOQLJPNAQL-UHFFFAOYSA-N
• Synonym: tetraethyl methylenediphosphonate, tetraethyl methanediphosphonate, tetraethyl diphosphonomethane, methylenebis diethylphosphonate, tetraethyl methylenebisphosphonate, phosphonic acid, methylenebis-, tetraethyl ester, methylenebis diethoxyphosphine oxide, methylenebisphosphonic acid, tetraethyl ester, phosphonic acid, methylenedi-, tetraethyl ester, methylenedi phosphonic acid tetraethyl ester
• PubChem CID: 15455
• SMILES: CCOP(=O)(CP(=O)(OCC)OCC)OCC

• Density: 1.162
• Boiling Point: 151°C to 153°C (1.2 mmHg)
• Flash Point: >110°C (230°F)
• Refractive Index: 1.44
• Quantity: 100 g
• Beilstein: 1813241
• Solubility Information: Slightly miscible with water.
• IUPAC Name: 1-[diethoxyphosphorylmethyl(ethoxy)phosphoryl]oxyethane
• Formula Weight: 288.22
• Percent Purity: ≥98%
• Chemical Name or Material: Tetraethyl methylenediphosphonate

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319 Causes skin irritation. Causes serious eye irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	216-764-5
RTECSNumber	SZ9150000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only