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Invitrogen™ TFF2 Polyclonal Antibody
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Catalog No. PIPA557781
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100 μL
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PIPA557781 100 μL
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Catalog No. PIPA557781 Supplier Invitrogen™ Supplier No. PA557781
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PHNRTNCGFP GITSDQCFDN GCCFDSSVTG VPWCFHPLPK QESDQCVMEV SDRRNCGYPG ISPEECASRK CCFSNFIFEV PWC Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 83%.

Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing and protection of the gastrointestinal epithelia. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. SP (spasmolytic polypeptide), also designated Trefoil factor 2 (TFF2) precursor, is a trefoil protein that functions to inhibit gastrointestinal motility and gastric acid secretion. SP may also act as a structural component of the gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. A downregulation of SP expression is associated with primary gastric cancer, and a progressive loss of this protein is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TFF2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Tff2
Gene Accession No. Q03403
Gene Alias mSP; pancreatic spasmolytic polypeptide; PSP; SML1; SP; spasmolysin; Spasmolytic polypeptide; spasmolytic protein 1; Tff2; Trefoil factor 2; trefoil factor 2 (spasmolytic protein 1)
Gene Symbols Tff2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TFF2. Recombinant protein control fragment (Product #RP-95295).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7032
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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