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Invitrogen™ TGFBR1 Recombinant Rabbit Monoclonal Antibody (PSH14-14)
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Catalog No. MA562931
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MA562931 100 μL
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Catalog No. MA562931 Supplier Invitrogen™ Supplier No. MA562931
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: THP-1 cell lysate, MCF7 cell lysate, SH-SY5Y cell lysate, Neuro-2a cell lysate, RAW264.7 cell lysate, C6 cell lysate. Tissue Specificity: Low tissue specificity Subcellular Location: Cell membrane, Cell junction, tight junction, Cell surface, Membrane raft. Sequence Similarities: 97.5% Mouse/Rat Predicted band size: 56 kDa.

TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
TRUSTED_SUSTAINABILITY

Specifications

Antigen TGFBR1
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone PSH14-14
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol, 0.1% BSA and 0.2% ProClin 950; pH 7.4
Gene TGFBR1
Gene Accession No. P36897, P80204, Q64729
Gene Alias AAT5; activin A receptor type II-like kinase, 53kDa; activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ACVRLK4; ALK5; Alk-5; AU017191; ESK2; ESS1; LDS1; LDS1A; LDS2A; MSSE; mutant transforming growth factor beta receptor I; ser; serine/threonine-protein kinase receptor R4; SKR4; TbetaRI; tbetaR-I; tgf beta receptor 1; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFBR1; TGFR1; TGFR-1; Transfor; transforming growth factor beta receptor 1; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa); transforming growth factor-beta receptor type I
Gene Symbols TGFBR1
Host Species Rabbit
Immunogen Recombinant protein within Human TGF beta Receptor I aa 34-503.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21812, 29591, 7046
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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