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Bachem (Des-Glu22)-Amyloid Beta Protein (1-40) Trifluoroacetate
Supplier: Bachem 4091431.1000
(Des-Glu22)-Amyloid Beta Protein (1-40) Trifluoroacetate, H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH, 1678416-36-8, C189H288N52O55S, Mr 4200.75, 1mg. Amyloid b-Protein (1-40) Osaka or Japanese Mutation, Amyloid b-Protein (1-40) E22D. The Osaka mutation was the first deletion-type mutation to be identified in APP and Ab. The Ab E22delta mutant is more resistant to degradation by two major Ab-degrading enzymes, neprilysin and insulin-degrading enzyme. Synthetic mutant Ab showed unusual aggregation properties with enhanced oligomerization but no fibrillization. It also inhibited hippocampal long-term potentiation more efficiently than wild-type Ab. A transgenic mouse model containing APP with the E693delta mutation has been developed. APP(OSK)-Tg mice exhibit intraneuronal Ab E22delta oligomers and memory impairment as early as eight months of age.
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