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Bachem Retrocyclin-1 Trifluoroacetate
SDP

Supplier:  Bachem 4045698.1000

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Retrocyclin-1 Trifluoroacetate, Cyclo(-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg), 724760-19-4, C74H128N30O18S6, Mr 1918.42, 1mg. RC-100. The theta-defensin retrocyclin-1, also called RC-100, is a circular octadecapeptide containing an internal trisulfide ladder. Besides its antimicrobial activity, retrocyclin-1 has a remarkable ability to protect human cells in vitro from infection by T- and M-tropic strains of HIV-1. Its effectiveness against HIV-1 results from the prevention of viral entry, and is correlated with its ability to recognize and bind with high affinity to glycoproteins and glycolipids implicated in HIV-1 entry, such as gp120 (KD = 35.4 nM), CD4 (KD = 31 nM), and galactosylceramide (KD = 24.1 nM). Retrocyclin represents a new class of small molecule HIV-1 entry inhibitors.

Catalog No. 50-194-6658


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