Invitrogen™ Thromboxane synthase Polyclonal Antibody

Catalog No.	Quantity
PIPA589188	100 μL

Catalog No. PIPA589188 Supplier Invitrogen™ Supplier No. PA589188

Description

Rabbit Polyclonal Antibody

Immunogen sequence: TYLLATNPDC QEKLLREVDV FKEKHMAPEF CSLEEGLPYL DMVIAETLRM YPPAFRFTRE AAQDCEVLGQ RIPAGAVLEM AVGALHHDPE HWPSPETFNP ERFTAEARQQ HRPFTYLPFG AGPRSCLGVR LGLLEVKLTL LHVLHKFRFQ ACPETQVPLQ LESKSALGPK NGVYIKIVSR; Positive Samples: THP-1, A-549, NCI-H460; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein.

Thromboxane synthase encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: Thromboxane synthase
• Applications: ELISA, Western Blot, Western Blot
• Classification: Polyclonal
• Concentration: 1.15 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: TBXAS1
• Gene Accession No.: P24557, P36423
• Gene Alias: BDPLT14; CYP5; Cyp5a1; cytochrome P450 5A1; cytochrome P450, family 5, subfamily A, polypeptide 1; FLJ52771; GHOSAL; platelet, cytochrome P450, subfamily V; similar to Thromboxane-A synthase (TXA synthase) (TXS); Tbxas1; THAS; ThromboxA ane synthase 1; thromboxane A synthase 1; thromboxane A synthase 1 (platelet); thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A); thromboxane A synthase 1, platelet; thromboxane synthase; thromboxane-A synthase; TS; TXA synthase; TXAS; TXS
• Gene Symbols: TBXAS1
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 355-534 of human Thromboxane synthase (NP_0010522).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 21391, 6916
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG