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Invitrogen™ TIE2 (TEK) Polyclonal Antibody
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Catalog No. PIPA580103 Shop All Thermo Scientific Products
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PIPA580103 100 μg
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Catalog No. PIPA580103 Supplier Invitrogen™ Supplier No. PA580103
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: MCF-7 whole cell.

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TIE2 (TEK)
Applications Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 5mg BSA and 0.05mg sodium azide
Gene TEK
Gene Accession No. Q02763, Q02858
Gene Alias AA517024; Angiopoietin-1 receptor; CD202B; CD202b antigen; EC 2.7.10; EC 2.7.10.1; Endothelial tyrosine kinase; endothelial-specific receptor tyrosine kinase; endothelium-specific receptor tyrosine kinase 2; endothelium-specific receptor tyrosine kinase Tie-2; hTIE2; Hyk; mTIE2; p140 TEK; protein-tyrosine kinase Tie2; STK1; Tek; TEK receptor tyrosine kinase; TEK tyrosine kinase, endothelial; TEKT1; Tektin-1; Tie2; tie-2; tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2; tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor Tie-2; VMCM; VMCM1
Gene Symbols TEK
Host Species Rabbit
Immunogen E.coli-derived human TIE2 recombinant protein (Position: Q641-I830).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21687, 7010
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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