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TIGIT Rat anti-Mouse, PE, Clone: GIGD7, eBioscience™ 
Rat Monoclonal Antibody
$143.00 - $331.00
Specifications
| Antigen | TIGIT |
|---|---|
| Clone | GIGD7 |
| Target Species | Mouse |
| Conjugate | PE |
| Isotype | IgG2a, kappa |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|
50-112-2442
|
Invitrogen
12950180 |
25 μg |
Each for $143.00
|
|
50-112-9360
|
Invitrogen
12950182 |
100 μg |
Each for $331.00
|
|
Description
Description: The GIGD7 monoclonal antibody reacts with mouse T cell immunoreceptor with Ig and ITIM domains (TIGIT, VSTM3, WUCAM), a 26 kDa protein that is a member of the poliovirus receptor (PVR) family. In mice, the expression of TIGIT has been reported in follicular T helper cells, while in humans, the expression of TIGIT has been reported on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells. TIGIT is not expressed on B cells or naive CD4+ T cells. TIGIT is upregulated on CD4+ T cells following activation. TIGIT can interact with certain members of the PVR and PVR-like families, including CD155, and also mediates the interaction of NK cells and T cells with antigen presenting cells, fibroblasts and endothelial cells that express PVR and PVR-like proteins. Applications Reported: This GIGD7 antibody has been reported for use in flow cytometric analysis. Applications Tested: This GIGD7 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 µm post-manufacturing filtered. Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.Specifications
| TIGIT | |
| Mouse | |
| IgG2a, kappa | |
| Monoclonal | |
| Liquid | |
| Antibody | |
| 4° C, store in dark, DO NOT FREEZE! |
| GIGD7 | |
| PE | |
| Flow Cytometry | |
| Primary | |
| Monoclonal | |
| PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2 | |
| RUO |
For Research Use Only.
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