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  6. TIM3 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 4C4G3, Proteintech 

TIM3 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 4C4G3, Proteintech
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Catalog No. 501736442 Shop All Proteintech Group Inc Products
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50-173-6442 150 μL
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Catalog No. 50-173-6442 Supplier Proteintech Group Inc Supplier No. 603551IG150UL
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Description

Mouse Monoclonal Antibody

TIM3 is a 280 aa membrane protein with a calculated molecular weight of 33 kDa, the higher molecular weights between 50 and 70 kDa detected by this monoclonal antibody probably represent glycosylated TIM3.

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.

Specifications

Antigen TIM3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 4C4G3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene HAVCR2
Gene Accession No. P0C0K5, Q8TDQ0, Q8VIM0
Gene Alias CD366, HAVcr 2, HAVCR2, KIM 3, T cell membrane protein 3, Tim 3, TIM3, TIM-3, TIMD 3, TIMD3
Gene Symbols Havcr2
Host Species Mouse
Immunogen TIM3 Fusion Protein Ag16901
Purification Method Protein G
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100522045, 171285, 363578, 84868
Target Species Human, Mouse, Pig, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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