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TLK2 Monoclonal Antibody (OTI2H2), TrueMAB™, OriGene
SDP

Catalog No. p-200013337
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100 μL
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Catalog No. Quantity
50-168-0725 100 μL
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Catalog No. 50-168-0725 Supplier OriGene Supplier No. TA805492
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Mouse Monoclonal Antibody

TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.

Specifications

Antigen TLK2
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone OTI2H2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene TLK2
Gene Accession No. Q86UE8
Gene Alias HsHPK, PKU-ALPHA
Gene Symbols TLK2
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 1-296 of human TLK2 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11011
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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