TLK2 Mouse anti-Human, Clone: OTI2G1, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF805458

Catalog No. 50-166-7437

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.

Specifications

• Antigen: TLK2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: TLK2
• Gene Alias: HsHPK, PKU-ALPHA
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11011
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2G1
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q86UE8
• Gene Symbols: TLK2
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-296 of human TLK2 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1