Invitrogen™ TMEM119 Polyclonal Antibody

Catalog No.	Quantity
PIPA562505	100 μL

Catalog No. PIPA562505 Supplier Invitrogen™ Supplier No. PA562505

Description

Rabbit Polyclonal Antibody

Immunogen sequence: GDGARMVEGR GAEEEEKGSQ EGDQEVQGHG VPVETPEAQE EPCSGVLEGA VVAGEGQGEL EGSLLLAQEA QGPVGPPESP CACSSVHPS Highest antigen sequence identity to the following orthologs: Mouse - 52%, Rat - 46%.

Tmem119 encodes a single-pass type I transmembrane protein which seems to interact with a multitude of micro-RNAs as well as certain transcription factors such as SMAD1, SMAD5 and RUNX2. Tmem119 has been identified as a surface marker of microglia that can be used to reliably distinguish microglia from infiltrating macrophages. Microglial cells are phagocytes that are restricted to the brain and involved in clearing up debris and dendrite pruning of neurons. They display a high functional plasticity, balancing neuroprotective and neurotoxic functions, which is reflected by their distinct physiology in response to changes in their microenvironment. Microglia are particularly mobile in areas of the brain undergoing restructuring. Reactive microglia co-express the marker Iba1. In a pathological context, microglia have been associated with differentiation of pathogenic/inflammatory A1 type astrocytes by secretion of Cq1, IL-1a and TNF when stimulated with LPS, and thought to contribute to the pathology of several neurodegenerative diseases such as Alzheimers, Parkinsons, Chorea Huntingtons disease and Multiple Sclerosis. The specific function Tmem119 plays on microglial cells remains unclear. Outside of the neural system, Tmem119 seems to be involved in osteoblast differentiation/ossification.

Specifications

• Antigen: TMEM119
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.10 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: TMEM119
• Gene Accession No.: Q4V9L6
• Gene Alias: AW208946; BC025600; OBIF; Osteoblast induction factor; PSEC0199; Tmem119; Transmembrane protein 119; UNQ731/PRO1415
• Gene Symbols: TMEM119
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human TMEM119. Recombinant protein control fragment (Product #RP-101539).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 338773
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG