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Invitrogen™ TM4SF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521119

Catalog No. PIPA521119


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Description

Description

A suggested positive control is human lung tissue lysate. PA5-21119 can be used with blocking peptide PEP-1233.

TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains and mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TM4SF1 is a cell surface antigen and is highly expressed in the vascular endothelium of several human cancers. Knockdown experiments of TM4SF1 prevented filopodia formation, inhibited cell mobility, blocked cytokinesis, and inhibited maturation of VEGF-A-induced angiogenesis, suggesting that TM4SF1 may be an attractive target for anti-angiogenesis therapy.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TM4SF1
Polyclonal
Unconjugated
TM4SF1
12A8 target antigen; H-L6; L6; L6 antigen; M3S1; Membrane component chromosome 3 surface marker 1; membrane component chromosome 3 surface marker 1 homolog; membrane component, chromosome 3, surface marker 1; membrane component, surface marker 1; TAAL6; TM4SF1; transmembrane 4 L six family member 1; transmembrane 4 L6 family member 1; transmembrane 4 superfamily member 1; tumor-associated antigen L6
Rabbit
Antigen Affinity Chromatography
RUO
17112, 295061, 4071
Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Liquid
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P30408, Q64302
TM4SF1
An 18 amino acid peptide near the amino terminus of human TM4SF1.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
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