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Invitrogen™ Tn Antigen Monoclonal Antibody (Tn 218)
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Catalog No. MA190544
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500 μL
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Catalog No. Quantity
MA190544 500 μL
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Catalog No. MA190544 Supplier Invitrogen™ Supplier No. MA190544
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Description

Mouse Monoclonal Antibody

MA1-90544 stains Tn antigen in epithelial carcinoma, pancreatic, colon, stomach and breast. A suggested positive control for this product is human gastrointestinal tumor. The antibody is supplied as concentrated tissue culture supernatant in PBS with 0.05% azide.

Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approximately 90% of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells. Fundamental, chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primamry breast carcinoma demonstrate its highly significant correlation with clinical pathological tumor stages, and hence its value as a reliable prognisticator.
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Specifications

Antigen Tn Antigen
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone Tn 218
Concentration 0.20 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide; pH 7.2
Gene Alias Thomsen-Friedenreich antigen
Host Species Mouse
Immunogen Asialo ovine submaxillary mucin (AOSM).
Purification Method Purified
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human, Mouse
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgM
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