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TNFR1 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 2A6E3, Proteintech
SDP

Catalog No. p-7212704 Shop All Proteintech Group Inc Products
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50-173-6295 150 μL
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Catalog No. 50-173-6295 Supplier Proteintech Group Inc Supplier No. 601921IG150UL
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Description

Mouse Monoclonal Antibody

TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal domit periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.

Specifications

Antigen TNFR1
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 2A6E3
Concentration 1.44 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TNFRSF1A
Gene Accession No. P19438, P22934, P25118, P50555
Gene Alias CD120a, FPF, p55, p55 R, p60, TBP1, TBPI, TNF R, TNF R I, TNF R1, TNF R55, TNF Receptor 1, TNF Receptor I, TNF RI, TNFAR, TNFR I, TNFR1, TNFR55, TNFR60, TNFRSF1A
Gene Symbols Tnfrsf1a
Host Species Mouse
Immunogen TNFR1 Fusion Protein Ag16112
Purification Method Protein G
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21937, 25625, 397020, 7132
Target Species Human, Mouse, Pig, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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