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TNNI3 Monoclonal Antibody (OTI8G8), TrueMAB™, OriGene
SDP

Catalog No. 501681857
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100 μL
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Catalog No. Quantity
50-168-1857 100 μL
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Catalog No. 50-168-1857 Supplier OriGene Supplier No. TA807946
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Description

Mouse Monoclonal Antibody

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Specifications

Antigen TNNI3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI8G8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene TNNI3
Gene Accession No. P19429
Gene Alias CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI
Gene Symbols TNNI3
Host Species Mouse
Immunogen Recombit protein expressed in E.coli corresponding to amino acids 1-210 of human TNNI3
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7137
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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