Tocris Bioscience Bay 55-9837
Potent and selective VPAC2 agonist
Manufacturer: Tocris Bioscience 2711/1
DescriptionSelective VPAC 2 receptor agonist (EC 50 values are 0.4, 100 and >1000 nM for VPAC 2 VPAC 1 and PAC 1 respectively in a cAMP accumulation assay; IC 50 values are 60, 8700 and >10000 nM for VPAC 2 VPAC 1 and PAC 1 respectively in a competition binding assay). Stimulates glucose-dependent insulin secretion in isolated human pancreatic islets. Reduces HIV-1 viral replication and shows cooperative effects when given in conjunction with VPAC 1 agonists.
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