Tocris Bioscience Compstatin
C3-binding protein, inhibits complement activation
Manufacturer: Tocris Bioscience 2585/1
DescriptionComplement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC 50 = 28 µM) and activation of classical and alternative complement pathways (IC 50 values are 63 and 12 µM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in baboons. Control Peptide also available.
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