Tocris Bioscience™ Cortistatin 14
Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2
Manufacturer: Tocris Bioscience™ 3374/1
DescriptionCortistatin 14 is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1, sst2, sst3, sst4 and sst5 receptors respectively). Also binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo. Also potent MRGPRX2 agonist.
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