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Tocris Bioscience™ Decanoyl-RVKR-CMK

Subtilisin/Kex2p-like proprotein convertase inhibitor

Manufacturer:  Tocris Bioscience™ 3501/1

Catalog No. 35-011

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Decanoyl-RVKR-CMK is a subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells. Also inhibits cleavage of SARS-CoV-2 spike protein by furin and blocks viral cell entry (IC50 = 57 nM in plaque reduction assay).


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