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Tocris Bioscience™ Gap 26

Catalog No. 19501
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19-501 1 mg
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Catalog No. 19-501 Supplier Tocris Bioscience™ Supplier No. 1950/1
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Description

Gap junction blocker; inhibits smooth muscle contraction and IP3-mediated ATP release

Gap 26 is a peptide, corresponding to residues 63 - 75 of connexin 43, which is a gap junction blocker. Attenuates rhythmic contractile activity of rabbit arterial smooth muscle (IC50 = 28.4 μM). Also inhibits IP3-induced ATP release, without inhibiting gap junctional coupling in endothelial cells.

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