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Tocris Bioscience™ GsMTx4
GSA_VAGREENER_CHOICE

Catalog No. 4912100U
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100 μg
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Catalog No. Quantity
49-121-00U 100 μg
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Catalog No. 49-121-00U Supplier Tocris Bioscience™ Supplier No. 4912/100U
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Description

TRPC1 and TRPC6 inhibitor; inhibits mechanosensitive ion channels

GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels. GsMTx4 blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells. GsMTx4 also inhibits TACAN, a mechanosensitive ion channel involved in the pain response. GsMTx4 decreases the leptin-induced AMPK and MLC-2 phosphorylation in breast epithelial cells. GsMTx4 is neuroprotective and inhibits lysophosphatidylcholine-induced astrocyte toxicity in vivo in mice. GsMTx4 suppresses neurogenesis and enhances astrogenesis in human neural stem cells.

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Specifications

CAS 1209500-46-8
Quantity 100 μg
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