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Tocris Bioscience™ Obtustatin
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Catalog No. 4664100U
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100 μg
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Catalog No. Quantity
46-641-00U 100 μg
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Catalog No. 46-641-00U Supplier Tocris Bioscience™ Supplier No. 4664/100U
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Description

Potent and selective α1β1 inhibitor

Obtustatin is a highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.

Specifications

Purity 95%
CAS 404882-00-4
Quantity 100 μg
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