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Invitrogen™ TOLLIP Polyclonal Antibody
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Catalog No. PIPA583431
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100 μL
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PIPA583431 100 μL
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Catalog No. PIPA583431 Supplier Invitrogen™ Supplier No. PA583431
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VEDKWYSLSG RQGDDKEGMI NLVMSYALLP AAMVMPPQPV VLMPTVYQQG VGYVPITGMP AVCSPGMVPV ALPPAAVNAQ PRCSEEDLKA Highest antigen sequence indentity to the following orthologs: Mouse - 88%, Rat - 88%.

Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TOLLIP
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TOLLIP
Gene Accession No. A2RUW1, Q9H0E2
Gene Alias 4930403G24Rik; 4931428G15Rik; adapter protein; EMBL:AAI33068.1}; FLJ33531; IL-1RAcPIP; toll interacting protein; toll-interacting protein; TOLLIP; tollip {ECO:0000312
Gene Symbols TOLLIP
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TOLLIP. Recombinant protein control fragment (Product #RP-97260).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361677, 54472
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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