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Topotecan hydrochloride, R&D Systems™
SDP

Catalog No. 456250 Shop All Novus Products
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Catalog No. Quantity
45-625-0 50 mg
45-6210 10 mg
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Catalog No. 45-625-0 Supplier R&D Systems Supplier No. 4562/50

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Description

A Tocris product, part of R&D Systems. DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog

Topotecan hydrochloride is a DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable. Topotecan disrupts the interaction between NHP2L1 and U4 RNA by binding to U4 and inhibits RNA splicing.

Chemical Identifiers

CAS 119413-54-6
Molecular Formula C23H23N3O5
Molecular Weight (g/mol) 421.45
MDL Number MFCD28989044
InChI Key UCFGDBYHRUNTLO-QHCPKHFHSA-N
Synonym topotecan hydrochloride, topotecan hcl, hycamptamine hydrochloride, topotecan monohydrochloride, unii-956s425zcy, topotecan hydrochloride usan, nogitecan hydrochloride, dsstox_cid_25952, dsstox_rid_81248
PubChem CID 60699
IUPAC Name (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
SMILES CC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=CC4=C(CN(C)C)C(O)=CC=C4N=C13)C2=O

Specifications

Quantity 50 mg
Formula Weight 457.91
Percent Purity >98%
Product Line Tocris
Chemical Name or Material Topotecan hydrochloride

Safety and Handling

Recommended Storage Store at -20°C
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