TP73 Mouse anti-Human, Clone: OTI1B5, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF506453

Catalog No. 50-166-4318

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

p73 protein is a member of the p53 family of proteins. The tumor-suppressor protein p53 exhibits sequence specific DNA-binding, directly interacts with various cellular and viral proteins, and induces cell cycle arrest in response to DNA damage. In response to signals generated by a variety of genotoxic stresses, e.g, UV irradiation or DNA damage, p53 is expressed and undergoes post-translational modification that results in its accumulation in the nucleus. Activation of p53 leads to cell cycle arrest and in some cases to apoptosis, resulting in the inability of genetically damaged cells to proliferate. Thus, the p53-dependent pathways help to maintain genomic stability by eliminating damaged cells. The accumulation of high levels of p53 is a potential marker for maligcy.

Specifications

• Antigen: TP73
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: TP73
• Gene Alias: P73
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7161
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1B5
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: O15350
• Gene Symbols: TP73
• Immunogen: Human recombit protein fragment corresponding to amino acids 167-409 of human TP73 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1